Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis
Identifieur interne : 002C43 ( Main/Exploration ); précédent : 002C42; suivant : 002C44Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis
Auteurs : Ernst Wagner [Autriche] ; David Curiel [États-Unis] ; Matt Cotten [Autriche]Source :
- Advanced Drug Delivery Reviews [ 0169-409X ] ; 1994.
English descriptors
- Teeft :
- Acad, Acta, Adenovirus, Adriamycin, Antitfr, Antitfr antibodies, Antitumor activity, Asialoglycoprotein receptor, Biochim, Biol, Biophys, Birnstiel, Bone marrow, Brain capillaries, Cancer inst, Cancer therapy, Cell lines, Chem, Chloroquine, Conjugate, Cotten, Cttfr, Curiel, Cytotoxic, Cytotoxic activity, Cytotoxicity, Delivery, Diphtheria, Diphtheria toxin, Drug delivery, Drug delivery reviews, Endocytosis, Endocytosis pathway, Endosomal, Endosomal membrane, Endosomes, Endothelial cells, Enhancement, Epidermal growth factor, Erythroid cells, Eukaryotic cells, Exotoxin, Fibroblast, Gene, Gene delivery, Gene expression, Gene transfer, Hawtrey, Hela cells, Hepatocytes, High levels, Immunotoxin, Immunotoxins, Influenza virus, Internal vesicles, Internalization, Intracellular, Leukemia, Leukemia cells, Leukemic, Leukemic cells, Ligand, Light units, Liposome, Mammalian cells, Methods enzymol, Monensin, Monoclonal, Monoclonal antibodies, Natl, Nucleic, Nucleic acids, Nude mice, Other groups, Pastan, Pathway, Peptide, Polycations, Polylysine, Primary cells, Proc, Protein toxins, Pseudomonas, Pseudomonas exotoxin, Raso, Receptor, Recombinant, Ricin, Toxicity, Toxin, Toxin conjugates, Toxin proteins, Transfected, Transfection, Transferrin, Transferrin receptor, Transferrin receptors, Trowbridge, Tumor cells, Unpublished results, Uptake, Various cell types, Vesicle, Viral, Viral genome, Virol, Vivo, Vivo gene transfer, Willingham, Youle, Zatloukal.
Abstract
Abstract: Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and on many kinds of tumors. The efficient cellular mechanism for uptake of transferrin has been subverted for the delivery of low-molecular-weight drugs, protein toxins, and liposomes by linkage of these agents to transferrin or to anti-transferrin receptor antibodies. Linkage may be via chemical conjugation procedures or by the generation of chimeric fusion proteins. Transferrin conjugated to DNA-binding compounds (e.g. polycations or intercalating agents) has been successfully used for the import of DNA molecules into cells. High-level gene expression is obtained only if endosome-disruptive agents such as influenza hemagglutinin peptides or adenovirus particles are included which release the DNA complex from intracellular vesicles into the cytoplasm.
Url:
DOI: 10.1016/0169-409X(94)90008-6
Affiliations:
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lines</term><term>Chem</term><term>Chloroquine</term><term>Conjugate</term><term>Cotten</term><term>Cttfr</term><term>Curiel</term><term>Cytotoxic</term><term>Cytotoxic activity</term><term>Cytotoxicity</term><term>Delivery</term><term>Diphtheria</term><term>Diphtheria toxin</term><term>Drug delivery</term><term>Drug delivery reviews</term><term>Endocytosis</term><term>Endocytosis pathway</term><term>Endosomal</term><term>Endosomal membrane</term><term>Endosomes</term><term>Endothelial cells</term><term>Enhancement</term><term>Epidermal growth factor</term><term>Erythroid cells</term><term>Eukaryotic cells</term><term>Exotoxin</term><term>Fibroblast</term><term>Gene</term><term>Gene delivery</term><term>Gene expression</term><term>Gene transfer</term><term>Hawtrey</term><term>Hela cells</term><term>Hepatocytes</term><term>High levels</term><term>Immunotoxin</term><term>Immunotoxins</term><term>Influenza virus</term><term>Internal vesicles</term><term>Internalization</term><term>Intracellular</term><term>Leukemia</term><term>Leukemia cells</term><term>Leukemic</term><term>Leukemic cells</term><term>Ligand</term><term>Light units</term><term>Liposome</term><term>Mammalian cells</term><term>Methods enzymol</term><term>Monensin</term><term>Monoclonal</term><term>Monoclonal antibodies</term><term>Natl</term><term>Nucleic</term><term>Nucleic acids</term><term>Nude mice</term><term>Other groups</term><term>Pastan</term><term>Pathway</term><term>Peptide</term><term>Polycations</term><term>Polylysine</term><term>Primary cells</term><term>Proc</term><term>Protein toxins</term><term>Pseudomonas</term><term>Pseudomonas exotoxin</term><term>Raso</term><term>Receptor</term><term>Recombinant</term><term>Ricin</term><term>Toxicity</term><term>Toxin</term><term>Toxin conjugates</term><term>Toxin proteins</term><term>Transfected</term><term>Transfection</term><term>Transferrin</term><term>Transferrin receptor</term><term>Transferrin receptors</term><term>Trowbridge</term><term>Tumor cells</term><term>Unpublished results</term><term>Uptake</term><term>Various cell types</term><term>Vesicle</term><term>Viral</term><term>Viral genome</term><term>Virol</term><term>Vivo</term><term>Vivo gene transfer</term><term>Willingham</term><term>Youle</term><term>Zatloukal</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and on many kinds of tumors. The efficient cellular mechanism for uptake of transferrin has been subverted for the delivery of low-molecular-weight drugs, protein toxins, and liposomes by linkage of these agents to transferrin or to anti-transferrin receptor antibodies. Linkage may be via chemical conjugation procedures or by the generation of chimeric fusion proteins. Transferrin conjugated to DNA-binding compounds (e.g. polycations or intercalating agents) has been successfully used for the import of DNA molecules into cells. High-level gene expression is obtained only if endosome-disruptive agents such as influenza hemagglutinin peptides or adenovirus particles are included which release the DNA complex from intracellular vesicles into the cytoplasm.</div></front></TEI><affiliations><list><country><li>Autriche</li><li>États-Unis</li></country><region><li>Alabama</li></region></list><tree><country name="Autriche"><noRegion><name sortKey="Wagner, Ernst" sort="Wagner, Ernst" uniqKey="Wagner E" first="Ernst" last="Wagner">Ernst Wagner</name></noRegion><name sortKey="Cotten, Matt" sort="Cotten, Matt" uniqKey="Cotten M" first="Matt" last="Cotten">Matt Cotten</name></country><country name="États-Unis"><region name="Alabama"><name sortKey="Curiel, David" sort="Curiel, David" uniqKey="Curiel D" first="David" last="Curiel">David Curiel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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